Validation study of a method for assaying DE-310, a macromolecular carrier conjugate containing an anti-tumor camptothecin derivative, and the free drug in human plasma by HPLC and LC/MS/MSOGUMA, Toshihiro; CICCI, Dino; GAUDETTE, Fleur et al.Journal of chromatography. B. 2005, Vol 818, Num 2, pp 249-256, issn 1570-0232, 8 p.Article

A novel method to load topotecan into liposomes driven by a transmembrane NH₄EDTA gradientYUEHUI YANG; YANLING MA; SHAONING WANG et al.European journal of pharmaceutics and biopharmaceutics. 2012, Vol 80, Num 2, pp 332-339, issn 0939-6411, 8 p.Article

Pharmacogenetic Pathway Analysis of IrinotecanROSNER, G. L; PANETTA, J. C; INNOCENTI, F et al.Clinical pharmacology and therapeutics. 2008, Vol 84, Num 3, pp 393-402, issn 0009-9236, 10 p.Article

Targeting atypical trypanosomatid DNA topoisomerase IBALANA-FOUCE, Rafael; REDONDO, Carmen M; PEREZ-PERTEJO, Yolanda et al.Drug discovery today. 2006, Vol 11, Num 15, pp 733-740, issn 1359-6446, 8 p.Article

Validation study of assay method for DE-310, a novel polymer-bound camptothecin derivative, and the free drug in mouse plasma by liquid chromatography with fluorimetric detectionOGUMA, Toshihiro; KONNO, Tomomi; NAKAOKA, Minoru et al.Journal of chromatography. B. 2004, Vol 801, Num 2, pp 157-164, issn 1570-0232, 8 p.Article

Renal Function as a Predictor of Irinotecan-induced NeutropeniaDE JONG, F. A; VAN DER BOL, J. M; MATHIJSSEN, R. H. J et al.Clinical pharmacology and therapeutics. 2008, Vol 84, Num 2, pp 254-262, issn 0009-9236, 9 p.Article

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line ModelsALLEN, Wendy L; COYLE, Vicky M; JOHNSTON, Patrick G et al.Clinical cancer research (Print). 2008, Vol 14, Num 20, pp 6647-6655, issn 1078-0432, 9 p.Article

Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agentsLIU, Ying-Qian; WEI DAI; WANG, Chih-Ya et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 24, pp 7659-7661, issn 0960-894X, 3 p.Article

Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and PharmacokineticsINNOCENTI, Federico; KROETZ, Deanna L; SCHUETZ, Erin et al.Journal of clinical oncology. 2009, Vol 27, Num 16, pp 2604-2614, issn 0732-183X, 11 p.Article

Irinotecan Side Effects Relieved by the Use of HI-6 Oxime: In Vivo Experimental ApproachLUCIC VRDOLJAK, Ana; BEREND, Suzana; ZELJEZIC, Davor et al.Basic & clinical pharmacology & toxicology (Print). 2009, Vol 105, Num 6, pp 401-409, issn 1742-7835, 9 p.Article

Antitumour drugs impede DNA uncoiling by topoisomerase IKOSTER, Daniel A; PALLE, Komaraiah; BOT, Elisa S. M et al.Nature (London). 2007, Vol 448, Num 7150, pp 213-217, issn 0028-0836, 5 p.Article

A Novel Camptothecin Derivative Incorporated in Nano-Carrier Induced Distinguished Improvement in Solubility, Stability and Anti-tumor Activity Both In Vitro and In VivoMIN HAN; HE, Cai-Xia; GAO, Jian-Qing et al.Pharmaceutical research. 2009, Vol 26, Num 4, pp 926-935, issn 0724-8741, 10 p.Article

Irinotecan Use During PregnancyTAYLOR, Justin; AMANZE, Adanna; DI FEDERICO, Elaine et al.Obstetrics and gynecology (New York. 1953). 2009, Vol 114, Num 2, pp 451-452, issn 0029-7844, 2 p., 2Article

The effect of 10-hydroxycamptothecine in preventing fibroblast proliferation and epidural scar adhesion after laminectomy in ratsYU SUN; LEI WANG; SIXIN SUN et al.European journal of pharmacology. 2008, Vol 593, Num 1-3, pp 44-48, issn 0014-2999, 5 p.Article

MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude miceFUJITA, Fumiko; KOIKE, Masako; KUDOH, Shinzoh et al.Clinical cancer research. 2005, Vol 11, Num 4, pp 1650-1657, issn 1078-0432, 8 p.Article

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effectsSAPRA, Puja; KRAFT, Patricia; PASTORINO, Fabio et al.Angiogenesis (London). 2011, Vol 14, Num 3, pp 245-253, issn 0969-6970, 9 p.Article

Enhancement of Radiation-induced DNA Damage and Inhibition of Its Repair by a Novel Camptothecin AnalogGE HUANG; HUIJUAN WANG; YANG, Li-Xi et al.Anticancer research. 2010, Vol 30, Num 3, pp 937-944, issn 0250-7005, 8 p.Article

Irinotecan Pharmacogenetics : Influence of Pharmacodynamic GenesHOSKINS, Janelle M; MARCUELLO, Eugenio; ALTES, Albert et al.Clinical cancer research. 2008, Vol 14, Num 6, pp 1788-1796, issn 1078-0432, 9 p.Article

Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacsXIANYI SHA; XIAOLING FANG.International journal of pharmaceutics. 2004, Vol 272, Num 1-2, pp 161-171, issn 0378-5173, 11 p.Article

Nigericin-mediated liposome loading of topotecan: Is nigericin a potential drug release regulator?JINGXIA CUI; CHUNLEI LI; CAIXIA WANG et al.International journal of pharmaceutics (Print). 2010, Vol 399, Num 1-2, pp 31-36, issn 0378-5173, 6 p.Article

Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ringSHENG WANG; YUYAN LI; YONGHUI LIU et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 4095-4097, issn 0960-894X, 3 p.Article

Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer PatientsSCHAIQUEVICH, Paula; PANETTA, John C; IACONO, Lisa C et al.Clinical cancer research. 2007, Vol 13, Num 22, pp 6703-6711, issn 1078-0432, 9 p., 1Article

Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicityCAO, Shousong; DURRANI, Farukh A; RUSTUM, Youcef M et al.Cancer chemotherapy and pharmacology. 2012, Vol 69, Num 4, pp 1107-1111, issn 0344-5704, 5 p.Article

The Role of the Transition Metal Copper and the lonophore A23187 in the Development of Irinophore CT™PATANKAR, Nilesh; ANANTHA, Malathi; RAMSAY, Euan et al.Pharmaceutical research. 2011, Vol 28, Num 4, pp 848-857, issn 0724-8741, 10 p.Article

Formulation and Comparative Characterization of Chitosan, Gelatin, and Chitosan-Gelatin-Coated Liposomes of CPT-11-HCISHENDE, Pravin; GAUD, Ram.Drug development and industrial pharmacy. 2009, Vol 35, Num 5, pp 612-618, issn 0363-9045, 7 p.Article